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Medical Achievements
  • The NTUH medical research team, consisting of the Department of Internal Medicine, led by Prof. Jia-Horng Kao and Dr. Chen-Hua Liu of the Hepatitis Research Center, and the Department of Surgery, led by Prof. Yih-Sharng Chen and Sheoi-Shen Wang, conducted the first clinical study in the world evaluating the efficacy and safety of interferon-free direct-acting antiviral agents, sofosbuvir plus ledipasvir or daclatasvir in chronic hepatitis C virus (HCV)-infected patients after receiving orthotopic heart transplantation. The study showed that the sustained virologic response (SVR) rate was 100% and treatment tolerance was good, and was published in the January 2018 issue of Clinical Infectious Diseases. This report has served as an important reference for the treatment of HCV-infected patients receiving non-liver solid organ transplantation, and has also been listed as a treatment recommendation in the European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases (AASLD) guidelines.
  • The medical team, led by Dr. Ting-Chen Chang from the Department of Obstetrics and Gynecology of NTUH, made a world-leading breakthrough in female pelvic organ prolapse treatment by developing an individually tailored transvaginal mesh that allows simultaneous surgical procedures on patients for both stress urinary incontinence and pelvic organ prolapse. This novel technique and device solve the problem of requiring two separate surgeries. The new surgical technique and device establishes a new standard for individualized treatment of these patients. The results have been published in Journal of BioMed Research International. This device has already been successfully patented in many countries, including Taiwan, Japan, China, and United States, and has received many awards.
  • The big data research team, led by Dr. Chien-Chang Lee from the Emergency Department of National Taiwan University Hospital discovered in 2015 that fluoroquinolone antibiotics can increase the occurrence of a rare but fatal disease of the aorta: aortic dissections or aortic aneurysm rupture. Dr. Lee employed a novel epidemiological design (a case-crossover and case-time-control design) to solve the potential confounding bias problem in the analysis of big health claims databases and confirmed the association between fluoroquinolone antibiotics and the risk of fatal aorta diseases. His findings were verified by researchers from Canada and Sweden, which triggered the change of the fluoroquinolone antibiotics prescription guideline by the FDA. The FDA now warns that the powerful drugs should only be used when absolutely necessary. The new warning will be added to the labels and prescribing guidelines of fluoroquinolone drugs. Fluoroquinolones are very commonly used antibiotics for treating pneumonia or urinary tract infection. Each year, tens of millions of fluoroquinolones are prescribed to elderly patients. Dr. Lee’s findings may help reduce the use of fluoroquinolones in elderly patients with minor infections, which can potentially save tens of thousands of people from developing fluoroquinolone-associated aortic dissection or aneurysm ruptures, thus saving thousands of lives annually. This is also the first time that a Taiwanese researcher’s finding has changed worldwide antibiotics treatment guidelines.
  • The medical team, led by Dr. Tsung-Lin Yang from the Department of Otolaryngology of NTUH, made a world-leading breakthrough in head and neck surgery by developing a trans-hairline approach to treat patients with head and neck tumors. The new surgical technique significantly reduces the surgical impact on head and neck appearance. The results have been published in Head & Neck, the leading journal of otolaryngology. What makes this new minimally invasive surgical procedure possible is the development of an innovative automatic mechanical wound opener for head and neck soft tissue (also referred to as Yang’s retractor). This device has already been successfully patented in the United States, Japan, and many other countries and has received numerous awards and recognition. This novel surgical technique successfully achieves an aesthetic outcome for patients after undergoing head and neck surgery.
  • Established a model for newborn screening of spinal muscular atrophy Spinal muscular atrophy (SMA) is the most common lethal inherited disease in newborns. In the most severe cases, infants exhibit at birth or soon after birth weakness and difficulty in breathing and feeding. Taking advantage of the universal newborn screening in Taiwan, it is possible to provide treatment to patients during the most ideal period, which is immediately after the symptoms occur, or even pre-symptomatically. With the parents’ consent, National Taiwan University Hospital’s Newborn Screening Center, in collaboration with all hospitals in Taiwan, used the same sample collected for newborn screening of inherited metabolic diseases to check if a baby had SMA. In total, around 120,000 newborns were screened and 8 were found to have SMA. Although one baby was unfortunately too severe to be treated, the other 7 babies were healthy and had not begun to exhibit any symptoms. Among them, 2 babies were successfully referred and received treatment before they exhibited symptoms. These results were published in the July 2017 issue of The Journal of Pediatrics.
  • The multicenter clinical study, led by professor Jou-Kou Wang of NTU’s Children’s Hospital, demonstrated a novel Palivizumab prophylaxis protocol for respiratory syncytial virus (RSV) infection. For children with congenital heart disease, this protocol can substantially reduce the hospitalization rate and severity of RSV infection. This is the first large-scale study in a subtropical and tropical area, and this protocol should be used as the treatment guideline for RSV prophylaxis. The results of this study have been published in The Journal of Pediatrics.
  • Ventricular tachycardia (VT) often causes severe symptoms, such as fainting, heart failure, shock, or even sudden death. VT in the pediatric population frequently causes life-threatening events requiring resuscitation. A study involving many centers around the world showed that the success rate of catheter ablation for left ventricular VT had a success rate of 71%, which is not ideal. Last year, NTUH reported that with ablation, a success rate as high as 90% for all VT patients and up to 93.9% for left ventricular VT patients were achieved. More importantly, many of the children who went into shock were successfully treated with ablation. These results have been published in the International Journal of Cardiology.
  • From 2012, our research team led by Professor Yeong-Shiau Pu and Dr. Chung-Hsin Chen proved that aristolochic acid (AA) was a main carcinogen of upper urinary tract urothelial carcinoma (UTUC) in Taiwan. The results of this study have been published in PNAS on May 22, 2012. We then focused on the carcinogenesis of AA and identified single base substitution frequency caused by AA was 10 times of that by other carcinogens, suggesting AA was a very potent carcinogen. In 2016, we reported the identification of TP53 mutation pattern as a part of personalized medicine for UTUC patients. The results of this study have been published in Oncotarget on June 7, 2016. Besides, we proved renal cell carcinoma was also affected by AA in Taiwan. The results of this study have been published in Cancer Epidemiol Biomarkers Prev. on December 25, 2016.

  • Professor Ho-Hsiung Lin of the Department of Obstetrics and Gynecology of National Taiwan University Hospital and Dr. Sheng-Mou Hsiao of the Department of Obstetrics and Gynecology of Far Eastern Memorial Hospital jointly published a study about re-treatment after discontinuation of antimuscarinic therapy or continuous antimuscarinic therapy for women with overactive bladder syndrome. The study found that frequent nocturia episodes, which is a suboptimal response, and small bladder capacity may predict persistent antimuscarinic therapy or re-treatment after solifenacin treatment of women with persistent or recurrent factors. The results of this study have been published in the online version of the journal Menopause on September 21, 2016.

  • Through a collaborative team effort, researchers from National Taiwan University Hospital (Department of Internal Medicine and Department of Medical Genetics), National Taiwan University College of Medicine and Academia Sinica discovered the genes that cause antithyroid drug-induced agranulocytosis. The results of this research were published in Nature Communications. 
  • A research team led by Dr. Chien-Chang Li, Director of the Department of Emergency Medicine at National Taiwan University Hospital Yun-Lin Branch, identified a novel association between fluoroquinolone treatment and the risk of aortic aneurysms or aortic dissection. The risk is approximately two times more when compared with non-users. It is the first time in the world this association has been verified by research. Because fluoroquinolone is one of the most commonly prescribed antibiotics, the finding has significant public health implication. The results of this research were published in JAMA Internal Medicine.
  • The pneumothorax research team, using a prospective randomized clinical trial, verified that the addition of mimocycline pleurodesis after the standard treatment of aspiration and drainage for primary spontaneous pneumothorax patients can effectively reduce the rate of recurrence and the probability of a follow-up operation. The study was published in The Lancet, a top medical journal, in 2013.
  • The liver transplantation team successfully harvested a right lobe from a living donor using robotic-assisted minimally invasive surgery.
  • The Fertility and Reproductive Medical Team of NTUH completed Asia's first successful case of preimplantation genetic diagnosis using blastocyst biopsy and array comparative genomic hybridization for women who suffer recurrent miscarriages caused by chromosomal translocation. A normal and healthy female baby was delivered in November 2011 (a press release was given in February 2012).
  • The Department of Medical Research of NTUH and the Department of Chemical Engineering of National Tsing Hua University collaborated to work on the latest Enterovirus (EV) vaccines. Using molecular biology techniques, the joint team researched and developed a virus-like particle (VLP) vaccine. Animal trails of this VLP vaccine on macaque monkeys were successfully completed. The results showed the animals developed a rather good concentration of antibodies, as well as the ability to neutralize EV-71. This research result was published in VACCINE, the pre-eminent journal for reports on all kind of vaccines. This research team is the international forerunner in the research and development of new vaccines for EV.
  • NTUH was the first in Asia to successfully complete a robotic assisted kidney transplant.
  • A multi-center randomized trial led by the Department of Internal Medicine of NTUH confirmed the usefulness of a novel sequential treatment as the first-line treatment for Helicobacter pylori infection - a common pathogen for stomach diseases. In this research, the authors extensively analyzed antibiotic resistance, designed a decision model that could predict the efficacy of anti-H. pylori treatment in different regions around the world, and disseminated an important message that the optimal regimen should be tailored to the local prevalence rate of the antibiotic resistant strains. The results of the study were published in one of the top medical journals, THE LANCET.
  • A long-term cohort study conducted by a NTUH medical group found that children born prematurely tend to develop more refractive errors, including myopia, hyperopia, and astigmatism. This finding has been published in the US Journal Investigative Ophthalmology and Vision Science.
  • Since 2001, NTUH’s chest surgery medical team has been applying chest endoscopy and laparoscopy for the purposes of esophagectomy and reconstruction. To this date, this team has successfully performed over 100 cases of endoscopic surgery for esophagectomy and reconstruction. Their research paper reporting this achievement has already been published by World Journal of Surgery, and also earned the honor of “2010 Outstanding Paper Award” from International Society for Diseases of the Esophagus (ISDE).
  • The“Center for Parkinson and Movement Disorders” was certified for the “Symbol of National Quality.
  • The advanced laparoscopic surgical team successfully completed a single-incision , minimally invasive laparoscopic appendectomy .It was the nation’s first case.
  • The successful treatment of a woodchuck with hepatoma using a mixture of multiple gene therapy and a research paper was published in the “Proceedings of the National Academy of Sciences of the United States of America (PNAS)”.
  • The Successful heart transplantation in a positive cross-match patient.
    picture of The Successful heart transplantation in a positive cross-match patient (1) picture of The Successful heart transplantation in a positive cross-match patient (2)
  • Successfully synthesized Metaiodobenzylguanidine (MIBG) scintigraphy, radiolabeled with iodine-123; independently produced the FDG, radiolabeled with fluorine-18 (F-18), and the F-DOPA, to detect and diagnose neuroblastoma.
  • Designed and developed a new surgical technique, single-hole laparoscopy-assisted gastrectomy, for the treatment of early gastric cancer. With this new method, the wound is only 2 cm in size. The patients can benefit with less pain, better outcome and earlier recovery.
  • Performed the first case in Asia using “Vagal Nerve Stimulator” to treat a young child with intractable epilepsy. This treatment can benefit those patients with intractable epilepsy who cannot be treated by intracranial surgery, antiepileptic medicine or ketogenic diet.
  • Announced successful treatment of recurrent corneal erosions with Nd:YAG laser. The success rate is 85%. The research result was published in “Ophthalmology” and was reported by “Eye World” magazine.
  • Department of Pediatrics, Department of Medical Genetics and Department of Surgery of NTUH worked as a team to provide an integrated treatment for an infant from Thailand born with Citrullinemia. This case has provided a building block for future international medical treatment for critical diseases.
  • Successfully performed Asia’s first case of Deep brain stimulation (DBS) to treat Parkinson disease. Compared with traditional surgery, this procedure can reduce operating time by three to four hours and is able to increase the accuracy rates by 46%.
  • Discovered a medicine for treating Niemann-Pick disease Type C. The new treatment successfully inhibits deterioration of the disease and improves the patients’ quality of life. European Union has approved this medicine for the treatment of Niemann-Pick disease Type C.
  • Introduced a groundbreaking technology in the diagnosis of Leukemia. It combines regular dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with an innovative analysis algorithm to select high-risk phenotype AML patients for tailored anti-angiogenic therapy, monitor treatment response and evaluate the outcome. The research result has been presented in Blood.
  • Successfully saved a drowning victim using Extra Corporeal Membrane Oxygenation (ECMO) for 117 days, the longest record of ECMO use in the world.
  • By applying genetic screening techniques to the in-vitro fertilization process, NTUH successfully helped a couple to have a healthy and HLA-matched baby girl. The baby’s cord blood was collect for cord blood transplantation. NTUH has conducted the Asia’s first cord blood transplant from a “rescue baby” to a boy with β-Thalassaemia Major.
  • Performed the first successful heart transplantation with the recipient under ECMO for 16 days without a heart. The Genetic Medicine Team at National Taiwan University Hospital has developed the world’s first newborn screening program for Pompe disease.
  • Performed the first successful Bicaval Heart Transplantation to treat both superior vena cava syndrome and severe heart failure in Taiwan.
  • Cooperated with Viet Duc hospital to perform the first living donor liver transplant in Vietnam. It was a great milestone and medical achievement in Vietnam.
  • Performed first Potassium-titanyl-phosphate Laser Nasopharyngectomy with nasopharyngoscopic guide for recurrent nasopharyngeal carcinoma.
  • World’s first pharmacogenomic testing to predict interferon therapy efficacy for treating chronic hepatitis C patients.
  • The first cross match positive live donor renal transplantation accomplished in Asia.
  • Conducted the world’s largest clinical trial of HPV vaccine for cervical cancer.
  • Set a new world record for the lightest premature baby (432 grams) to successfully undergo intestinal anastomosis by exploratory laparotomy.
  • The first patient with server acute respiratory syndrome (SARS) in Taiwan was recognized. Cared for most SARS patients.
  • Successfully performed the first mini-allogeneic transplantation treatment of nasopharyngeal carcinoma in the world.
  • Created a unique treatment modality for advanced nasopharyngeal carcinoma (NPC) with the highest cure rare in the world, performed by Drs. Ko, Hong, and Ru (KHR).
  • Application of Cutaneous Epidermal Cell to Treat Limbal Insufficiency.
  • First successful heart transplantation for the youngest patient (6 months of age) in Asia.
  • First in Asia to perform stereotactic microeletrode pallidotomy for Parkinsonism
  • First successful cardiac cryosusrgery in the world.
picture of First successful cardiac cryosusrgery in the world
  • Successful surgery for the oldest hepatoma patient (93yrs) ever recorded in the medical literature.
  • First successful artificial heart transplant in Asia.
  • First in Asia to implant an artificial heart (biventricular-assist device) and successfully sustaining the patient until a heart transplant.
  • Scalp micro-skin grafting invented by Prof. T-W Lin.
  • First successful simultaneous heart - kidney transplantation in NTUH.
  • Conducted the three-dimensional ultrasound examination using TOM-TEC workstation and accomplished the first surface-rendered fetal face of Taiwan.
  • First successful lung transplantation in NTUH.
  • Conducted Taiwan’s first implantable cardioverter-defibrillator (ICD) surgery.
  • Performed Taiwan’s first pancreatic transplant.
  • Performed Taiwan’s first umbilical cord blood transplant to replace bone marrow.
  • First successful Domino operation ( in Taiwan) for heart transplantation.
  • Performed Taiwan’s first cochlear implant surgery.
  • Performed the world’s first aspiration of fetal ascites.
  • Performed separation of premature conjoined twins joined at the chest and abdomen, setting a new world record for the lightest weight for this type of surgery.
  • Started transcatheter closure of patent ductus arteriosus.
  • Performed Taiwan’s first case of high-dose chemotherapy and peripheral blood stem cell transplant.
  • Performed Taiwan’s first pediatric liver transplant surgery.
  • Successful separation for thoraco-abdominal conjoined male twins.
  • Successfully completed an arterial switch operation on its youngest patient ever.
  • Taiwan’s first 1.5T MRI scanner becomes operational.
  • First successful liver transplantation in NTUH.
  • Successful heart transplantation for the youngest patient in Asia.
  • Delivered Taiwan’s first frozen embryo test-tube baby.
  • Performed Taiwan’s first heart transplant surgery.
  • Delivered its first test-tube baby.
  • The first patient with acquired immunodeficiency syndrome in Taiwan was recognized.
  • Successful separation for ischiopagus tripus conjoined female twins, the smallest patient in the world ever documented.
  • First case of fetal blood sampling.
  • First percutaneous nephrolithstripsy.
  • Performed Taiwan’s first allogeneic bone marrow transplant.
  • Performed Taiwan’s first autologous bone marrow transplant.
  • First brain ultrasonography in newborns.
  • Successful separation for thoraco-abdominal conjoined female twins.
  • Successfully separated the conjoined twins Chung-jen and Chung-yi.
  • Started first real-time ultrasound examination in Taiwan.
  • Performed first W.P.W syndrome ablation operation.
  • First in Taiwan to implant modern pacemaker which can last for 10 years to cardiac patient.
  • First total shoulder replacement surgery.
  • First linear accelerator for cancer radiotherapy in Taiwan.
  • First successful triple valves replacement surgery in Taiwan.
  • Started first blood cell separator.
  • First successful Rastelli procedure for correction of transposition of great arteries.
  • First tendon grafting with allograft.
  • First successful Mustard procedure ( atrial-switch operation) in Taiwan for transposition of great arteries.
  • Conducted first videoendoscopic examination In Far East Area.
  • First successful operation in Taiwan for Cerebrovascular disease.
  • First total elbow replacement surgery.
  • Performed Taiwan’s first successful coronary artery bypass surgery, by Prof. Shu-hsun Chu and others.
  • First replantation surgery for finger amputation .
  • First Cobalt-60 unit (Theratron 80) for cancer treatment in Taiwan.
  • First artificial genitoplasy.
  • Started the research of hepatitis B virus(HBV) surface antigen.
  • Performed Taiwan’s first permanent pacemaker implantation.
  • Performed Taiwan’s first cadaveric renal transplant.
  • Inserted Taiwan’s first temporary pacemaker.
  • Performed Asia’s first successful living donor kidney transplant, by Prof. Chun-jen Lee and others.
  • Started to perform hemodialysis.
  • Performed first open heart surgery, by Prof. Tien-yu Lin and others.
  • First cardiac catheterization in children.
  • Conducted Taiwan’s first hemodialysis treatment using an electrodialysis-type artificial kidney.
  • Started using Cobalt-60 therapy.
  • The radioisotope laboratory began iodine-131 therapy.
  • Successfully liver resection with finger fracture method created by Prof. T. Y. Lin.
  • First in Taiwan to purchase and use a gastroscope to carry out upper gastrointestinal endoscopy diagnostic procedures.
  • Liu's stain, a fast and convenient staining technique invented by Prof. Liu, is applied to daily practice till now.
  • Dr. Liu's Chin-Hui designed the preumo-apparatus.
  • Conducted first proctoscopic examination.
  • Sadamu Yokogawa was awarded for identification of Metagonimus yokogawai .
Last modified at 2018/04/13
Data from Secretariat Office